Buprenorphine Treatment for Opiate Addiction-2017

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Why doesn't everyone who takes opioids become addicted?

about 10% of those prescribed opioid medications become addicted


Summary:

Pain can offset the euphoria
otherwise produced by the opioids. Without a net excess of induced euphoria, the
reward system is not triggered
and the
addiction process never begins
.
Physical dependence and tolerance do form
, but both are easily remedied in the absence of addiction.
Addiction medications maintain tolerance and physical dependence
while allowing for the
behavioral changes necessary for addiction remission
. Although it's possible for someone to become addicted to the buprenorphine, it is uncommon.

Why Some Get Addicted and Not Others

Not everyone who takes opioids will become addicted. In fact most people who take opioid medication do not become addicted, even some on high doses for long periods of time. Although many will develop tolerance and physical dependence, only a minority develop the compulsive and uncontrollable behaviors of addiction. Part of understanding this is knowing the profound difference between physical dependence and addiction. Understanding why people don't become addicted helps us in understanding addiction itself.

Reward System Stimulation

We learned earlier that addiction forms as a result of repeated stimulation of the brain's reward system. The brain interprets the flood of opioids as an indication of a positive experience necessary for survival. The unnatural level of opioid stimulation exceeds what the brain is equipped to handle and the result alters the brain and produces persistent strong cravings long after opioids are stopped.

However, if a patient is in pain, the opioids merely offset feelings of pain, instead of causing intense euphoria. While pain is present, and while dosed to match, the unnaturally high levels of euphoria are never created to trigger the reward cycle. Without the repeated high euphoria, associations are not created and the compulsive condition does not form.

Tolerance, Physical Dependence, Addiction

Other processes such as the development of tolerance and physical dependence occur just as they would with those on the path to addiction. Dose requirements rise to maintain a constant level of pain suppression. Eventually, tolerance rises to the point of physical dependence whereas the patient would experience withdrawal if they were to stop the opioids abruptly or sharply decrease their dose. Withdrawal does not indicate addiction.

Chronic pain patients who manage to take enough opioids to reduce pain but not enough to induce a net high euphoric response, generally don't develop addiction but do developed tolerance and physical dependence. For them, a taper off of the opioids when no longer needed reduces withdrawal symptoms to low levels with little if any longer term symptoms.

Contrast this with a person who has developed tolerance and physical dependence along with addiction. They can resolve the physical dependence with a slow taper as well, if they are able to control the cravings. However unlike the non-addicted person, after the taper, the brain adaptations associated with addiction will produce lingering symptoms of anxiety, depression, lethargy and cravings which could last for months. These post acute-withdrawal symptoms often lead patients to relapse. This is why detox treatment are notoriously unsuccessful. It may also explain why some say that they are "in recovery" rather than" recovered", as fighting the symptoms becomes a never-ending experience. However, coping with the brain changes of addiction may not be the only choice. Reversing the brain adaptations may greatly reduce their ability to cause long-term symptoms, and that is what evidence-based medication assisted treatment with buprenorphine is all about.

Genetics and Environment Can Contribute

Many factors can disrupt the balance of the level of euphoria with the level of pain, placing the patient at greater risk for the development of addiction. Continuing to take the medication after the pain has passed is one example. Genetic factors also can make one person more susceptible to addiction than others. Stress, depression, anxiety and environmental facts can all contribute to the decision to take more medication than is warranted by the pain.

Buprenorphine is Different

Evidence-based addiction treatment consists of reversing, to the extent possible, the brain adaptation of addiction, before tapering off opioids completely. This is where treatment medications such as buprenorphine can help. Although it is possible for some to develop cravings and uncontrollable compulsions toward buprenorphine, generally patients maintain control of their buprenorphine use. Buprenorphine does not cause a high euphoric response and blocks the effects of other opioids which might. Thus the stimulation of the reward system is stopped, allowing the patient to undo some of the damage via a deliberate reconditioning process. Meanwhile a slow taper of the buprenorphine slowly resolves the physical dependence.

It's buprenorphine's suppression of cravings which makes the necessary behavioral changes possible. Although some of the tolerance and physical dependence is maintained while in buprenorphine treatment, the craving-causing brain adaptations of addiction are allowed to diminish. Since buprenorphine treatment does not perpetuate the reward/craving cycle, the patient is free to make significant behavioral changes which would be more difficult if cravings and withdrawal were present.

More on addiction to buprenorphine itself



Notes:

  1. Brand names for buprenorphine/naloxone (bup/nx)

    combination products in the US:
    Suboxone Film
    ,
    Zubsolv
    ,
    Bunavail
    , and generic equivalents of the discontinued Suboxone Sublingual Tablets.
  2. Buprenorphine products in the US WITHOUT the added naloxone

    safeguard:
    1. Subutex Tablets
      (
      discontinued in 2009
      ) but the
      generic equivalents remain available
      .
    2. Buprenex®
      is an injectable,
      FDA approved for pain
      NOT addiction -
      illegal to prescribe for opioid addiction
      .
    3. Butrans®
      Patch, also
      FDA approved for pain
      and NOT addiction -
      illegal to prescribe for opioid addiction
      .
    4. Pharmacy-compounded bup or bup/nx
      preparations - NOT FDA approved for addiction -
      illegal to prescribe for opioid addiction
      .
  3. Probuphine®
    is an insertable
    buprenorphine rod
    which goes under the skin and releases bup over the course of 6 months. It
    was FDA approved in May of 2016
    , and is for the treatment of addiction.
  4. Belbuca™
    is a
    buprenorphine film
    which goes on the inside of the cheak. It
    was FDA approved in October of 2015
    , and is for the treatment of pain - NOT FDA approved for addiction -
    illegal to prescribe for opioid addiction
    .
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  1. Nothing on this site should be confused for medical advice. The information provided here should only serve to inspire you to find out more from credible sources. We hope to help you understand the disease better so that you know what questions to ask your doctor. Never take any online medical advice over that of a healthcare professional, assume it's all made up. Despite the links to peer reviewed studies all interpretations of said studies may be opinion, unreliable or erroneous. If some patients found something beneficial to them it's not an indication that it will be beneficial to you, on the contrary, it may be dangerous. You, not us, are responsible for what you do with the information you get from this site or any site.

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