Buprenorphine Treatment for Opiate Addiction-2024


Buprenorphine Side Effects

Headache, Constipation, Dry Mouth, Sexual Dysfunction


When at the optimal dose, four side effects are experienced most often;
Headache, Constipation, Dry mouth, and low libido
Keeping well hydrated often takes care of the first three.
But when that is not enough over the counter medications can help. A wider variety of
side effects occur when the dose is incorrect
Finding the correct dose is the first step
to eliminating side effects.
The correct dose is the lowest dose which still suppresses cravings and withdrawal


Many medications can cause constipation, including opioids, but especially long-acting opioids. Fast-acting, short-duration opioids, such as heroin and hydrocodone, produce periods of great effect followed by periods of lesser effect. It is during those periods of lesser effect that the body is able to produce bowel movements. However, long-acting opioids, such as buprenorphine, methadone and time-released oxycodone, have a continuous influence on the body without the period of lesser effect that would allow for bowel movements. This can lead to chronic constipation if preventative strategies aren't employed.

Constipation can become serious, and, in extreme cases, require surgery, but for most, it's an unnecessary inconvenience and discomfort. Fortunately, it is usually avoidable with dose/formulation changes, OTC remedies, exercise, good diet and good hydration.

If drinking more water along with a high fiber diet and increased exercise isn't enough, stool softeners such as docusate sodium (brand name Colace®) which comes in soft gel tablets are an option. This product softens stools and has a lubricating effect, but is not a laxative. Polyethylene glycol 3350 (brand name Miralax®) is a powder that dissolves into drinks and both softens stools and increases the frequency of bowel movements. It works by drawing water into the colon, and for that reason drink plenty of water to avoid dehydration - a contributor to constipation. According to an informal survey conducted online, either one or a combination of both has been effective at relieving most buprenorphine-induced constipation. Avoid harsh and habit-forming laxatives if possible; and, of course, consult your doctor before using any of the remedies mentioned here.

New formulations of buprenorphine have better bioavailability, and as a result, less bupe is required. The theory is if there is less buprenorphine in total, less will get diverted to the GI track (thought to be a contributor to opioid-induced constipation) and constipation should be reduced.

Too Late - I have severe constipation now, what can I do?


Headache is one of the most commonly reported buprenorphine side effects. A common remedy for headaches is aspirin or other OTC pain remedies with a glass of water; but water alone may be all that's needed. Medications, including laxatives and all opioids, can contribute to dehydration; and one of the first symptoms of dehydration is a headache. Just staying hydrated throughout the day may be enough to solve the headache side effect, and reduce some of the other side effects as well.

Be mindful there are other things that can cause headaches such as caffeine and nicotine withdrawals. Drinking plenty of water is the easiest first step in trying to figure out the cause of headaches. But if the headaches persist, consult with a medical professional to be on the safe side.

Dry mouth (xerostomia):

This may seem like an innocuous symptom and is not often cited as a buprenorphine side effect, but it can be very serious and very costly.

Saliva is the mouth's primary defense against tooth decay, gum disease, and maintains the health of the soft and hard tissues in the mouth. Saliva washes away food and other debris, neutralizes acids produced by bacteria in the mouth and provides disease-fighting substances throughout the mouth.

With dry mouth (which is a side effect from all opioids) these benefits are diminished which allows bacteria to multiply and often leads to gingivitis which can lead to periodontitis disease, and eventually bone and tooth loss.

  • Gingivitis: This is the earliest stage of gum disease, some bleeding with brushing and inflammation of your gums caused by plaque buildup at the gumline. At this early stage in gum disease, damage can be reversed, since the bone and connective tissue that hold the teeth in place are not yet affected.

  • Periodontitis: At this stage, the supporting bone and fibers that hold your teeth in place are irreversibly damaged. Your gums may begin to form a pocket below the gumline, which traps food and plaque. Proper dental treatment and improved home care can usually help prevent further damage.

  • Advanced Periodontitis: In this final stage of gum disease, the fibers and bone supporting your teeth are destroyed, which can cause your teeth to shift or loosen. This can affect your bite and, teeth may need to be removed.

Bacteria in plaque are the main cause of gingivitis and periodontitis. Plaque is a biofilm that continuously forms on the teeth and under the gumline. These bacteria may release toxins, especially below the gumline, that irritate the gum tissue and cause inflammation. Toxins or poisons - produced by the bacteria in plaque as well as the body's "good" enzymes involved in fighting infections - start to break down the bone and connective tissue that hold teeth in place. The gums may eventually break down and separate from the teeth causing a deep space called periodontal pockets. These pockets are very difficult to clean, allowing the bacteria to grow and multiply. As the disease progresses, the pockets deepen and more gum tissue and bone are destroyed. When this happens, teeth are no longer anchored in place, they become loose, and tooth loss occurs.

Other contributors to the risk and severity of periodontal gum disease and oral health problems are smoking and diabetes.

According to the CDC, researchers have uncovered potential links between gum disease and other serious health conditions. In people with healthy immune systems, the bacteria in the mouth that makes its way into the bloodstream is usually harmless. But under certain circumstances, these microorganisms are associated with health problems such as stroke and heart disease.

Avoid the pain and cost from the consequences of buprenorphine-induced dry mouth by keeping well hydrated, use OTC treatment for dry-mouth such as Biotene®, and pay especially close attention to good oral hygiene with routine dentist visits. Water flossers may be even more effective than floss at reducing plaque buildup. Preventative oral care might be the single best way to save money associated with your addiction treatment. Do not overlook the importance of it.

Sexual Dysfunction

Buprenorphine, like all opioids, can reduce libido. This can be a good thing as it might prevent someone from becoming pregnant, until they have resolved their addiction. But it may not seem like a good thing to others. This is a common and well known side effect. It is dose related so lower doses have less impact on libido. Exercise, good nutrition, adequate rest, and/or a sexier partner can help.

Above buprenorphine side effects can occur when dosed correctly. When dosed incorrectly however, other symptoms have been reported. Here are some of them.

  • Too high of a dose: lethargy, a medicated feeling ( described as " cloudy" "foggy" or " slow"), tiredness, nausea, constricted pupils in low light, a general unmotivated feeling, unjustified feeling of contentment, dehydration (indicated by dark urine)

  • Too low of a dose: sweating, chills, goose bumps, dilated pupils in normal light, diarrhea, cramps, insomnia, nausea, anxiety, depression, dehydration, cravings

The optimal dose of buprenorphine, when prescribed for addiction, is the lowest dose that suppresses cravings and withdrawal symptoms. Dose requirements may change as treatment progresses.

  1. National Alliance of Advocates for Buprenorphine Treatment- www.NAABT.org
  2. Anecdotal evidence compiled from several social media sites over a period of several years
  3. Zubsolv full prescribing information submitted to the FDA - Zubsolv PI
  4. Bunavail full prescribing information submitted to the FDA - Bunavail PI
  5. Suboxone Film full prescribing information submitted to the FDA - Suboxone Film PI
  6. TIP-40, buprenorphine treatment clinical guidance - government document 2004


  1. Brand names for buprenorphine/naloxone (bup/nx)

    combination products in the US:
    Suboxone Film
    Bunavail(discontinued in 2020)
    , and generic equivalents of the discontinued Suboxone Sublingual Tablets.
  2. Buprenorphine products in the US WITHOUT the added naloxone

    1. Subutex Tablets
      discontinued in 2009
      ) but the
      generic equivalents remain available
    2. Buprenex®
      is an injectable,
      FDA approved for pain
      NOT addiction -
      illegal to prescribe for opioid addiction
    3. Butrans®
      Patch, also
      FDA approved for pain
      and NOT addiction -
      illegal to prescribe for opioid addiction
    4. Pharmacy-compounded bup or bup/nx
      preparations - NOT FDA approved for addiction -
      illegal to prescribe for opioid addiction
  3. Probuphine®
    is an insertable
    buprenorphine rod
    which goes under the skin and releases bup over the course of 6 months. It
    was FDA approved in May of 2016
    , and is for the treatment of addiction.
  4. Belbuca™
    is a
    buprenorphine film
    which goes on the inside of the cheek. It
    was FDA approved in October of 2015
    , and is for the treatment of pain - NOT FDA approved for addiction -
    illegal to prescribe for opioid addiction
  5. Sublocade™
    , from the makers of Suboxone®, is a once-monthly buprenorphine subcutaneous injection, FDA approved 11/2017 for the treatment of opioid use disorder (opioid addiction).
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  1. Nothing on this website should be confused for medical advice. The information provided here should only serve to inspire you to find out more from credible sources. We hope to help you understand the disease better so that you know what questions to ask your doctor. Never take any online medical advice over that of a healthcare professional, assume it's all made up. Despite the links to peer reviewed studies all interpretations of said studies may be opinion, unreliable or erroneous. If some patients found something beneficial to them it's not an indication that it will be beneficial to you, on the contrary, it may be dangerous. You, not us, are responsible for what you do with the information you get from this website or any website.

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